Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease

Figure 2 Mediating role of metabolic and inflammatory indicators in the healthy sleep score and metabolic dysfunction-associated steatotic liver disease relationship. A: Mediating role of remnant cholesterol in the healthy sleep score (HSS)-metabolic dysfunction-associated steatotic liver disease (MASLD) association; B: Mediating role of non-high-density lipoprotein cholesterol (non-HDL-C) in the HSS-MASLD association; C: Mediating role of homeostasis model assessment of insulin resistance (HOMA-IR) in the HSS-MASLD association; D: Mediating role of high-sensitivity C-reactive protein in the HSS-MASLD association. Diabetes was not adjusted for in the covariates when HOMA-IR was as the mediator. ^aP < 0.05; ^bP < 0.001. MASLD: Metabolic dysfunction-associated steatotic liver disease; RC: Remnant cholesterol; Non-HDL-C: Non-high-density lipoprotein cholesterol; HOMA-IR: Homeostasis model assessment of insulin resistance; hs-CRP: High-sensitivity C-reactive protein; HSS: Healthy sleep score.