Recurrence patterns and outcomes of symptomatic gallstone disease in the elderly

Table 3 Median time to first recurrence and type of recurrence by each gallstone disease at index admission and age, n (%)/median (interquartile range)

Index admission cause	Age	Total recurrences (n = 1021)	Median time until first recurrence		Type of recurrence
			Months	P value	Acute pancreatitis	Acute cholecystitis	Acute cholangitis	SC	BC	Any combination	P value
Acute pancreatitis	< 80	255 (37.0)	2.1 (0.7, 4.5)		146 (57.3)	16 (6.3)	8 (3.1)	14 (5.5)	59 (23.1)	12 (4.7)
	≥ 80	91 (36.1)	3.5 (1.5, 9.7)	0.002	51 (56.0)	9 (9.9)	5 (5.5)	5 (5.5)	10 (11.0)	11 (12.1)	0.027
Acute cholecystitis	< 80	150 (32.4)	1.9 (0.6, 4.4)		13 (8.7)	56 (37.3)	8 (5.3)	7 (4.7)	62 (41.3)	4 (2.7)
	≥ 80	134 (36.4)	2.8 (0.9, 7.3)	0.001	4 (3.0)	54 (40.3)	20 (14.9)	8 (6.0)	35 (26.1)	13 (9.7)	< 0.001
Acute cholangitis	< 80	62 (32.8)	2 (0.5, 6.2)		3 (4.8)	11 (17.7)	20 (32.3)	7 (11.3)	17 (27.4)	4 (6.5)
	≥ 80	45 (23.7)	3.6 (0.9, 11.5)	0.102	3 (6.7)	16 (35.6)	11 (24.4)	4 (8.9)	10 (22.2)	1 (2.2)	0.368
SC	< 80	63 (30.3)	0.9 (0.5, 2.4)		9 (14.3)	9 (14.3)	7 (11.1)	15 (23.8)	22 (34.9)	1 (1.6)
	≥ 80	22 (23.4)	3.2 (0.5, 12.6)	0.049	1 (4.5)	7 (31.8)	4 (18.2)	8 (36.4)	2 (9.1)	0 (0.0)	0.082
BC	< 80	93 (37.1)	1.6 (0.4, 3.5)		14 (15.1)	13 (14.0)	1 (1.1)	3 (3.2)	61 (65.6)	1 (1.1)
	≥ 80	25 (39.7)	5.8 (2.5, 8.9)	< 0.001	4 (16.0)	8 (32.0)	3 (12.0)	2 (8.0)	7 (28.0)	1 (4.0)	0.004
Any combination	< 80	45 (34.9)	1.4 (4.2, 4.9)		11 (24.4)	8 (17.8)	5 (11.1)	2 (4.4)	11 (24.4)	8 (17.8)
	≥ 80	36 (30.0)	3.8 (0.9, 13.8)	0.038	5 (13.9)	11 (30.6)	6 (16.7)	1 (2.8)	9 (25.0)	4 (11.1)	0.589
All	< 80	668 (35.8)	1.8 (0.6, 4.2)		196 (29.3)	113 (16.9)	49 (7.3)	48 (7.2)	232 (34.7)	30 (4.5)
	≥ 80	353 (32.5)	3.4 (1.1, 9.1)	< 0.001	68 (19.3)	105 (29.7)	49 (13.9)	28 (7.9)	73 (20.7)	30 (8.5)	< 0.001

BC: Biliary colic; SC: Symptomatic choledocholithiasis.