Effects of Lactiplantibacillus plantarum 299v and Lactiplantibacillus plantarum GOS42 on gastrointestinal symptoms in healthy adults with occasional constipation

Table 3 Complete spontaneous bowel movements per week in subjects with ≤ 3 complete spontaneous bowel movements per week at baseline, mean ± SD

	ITT L. plantarum(n = 37)	ITT placebo (n = 43)	P value, between groups	PP L. plantarum(n = 36)	PP placebo (n = 41)	P value, between groups
Baseline	1.6 ± 1.2	1.2 ± 1.2	0.1381	1.6 ± 1.2	1.2 ± 1.2	0.1411
Week 4	3.3 ± 3.0	2.5 ± 2.3	0.2121	3.3 ± 3.0	2.3 ± 2.1	0.1391
Week 8	4.5 ± 3.0	3.1 ± 2.5	0.0281	4.6 ± 3.0	3.0 ± 2.5	0.0151
Change baseline-week 4	1.7 ± 3.1a	1.3 ± 2.1b	0.3562	1.7 ± 3.2a	1.2 ± 2.0b	0.2442
Change baseline-week 8	2.9 ± 3.0b	1.9 ± 2.4b	0.0482	3.0 ± 3.0b	1.8 ± 2.4b	0.0242

^aP < 0.01 vs baseline (paired t-test).

^bP < 0.001 vs baseline (paired t-test).

¹t-test.

²Linear mixed model analysis.

ITT: Intention-to-treat; PP: Per-protocol; L. plantarum: Lactiplantibacillus plantarum.