First large-scale prospective evaluation of serum S100A6 as a complementary biomarker for early pancreatic cancer detection

Figure 3 Receiver operating characteristic curves for single biomarkers (S100A6, carbohydrate antigen 19-9, and carcinoembryonic antigen) in the diagnosis of pancreatic cancer. A: Receiver operating characteristic curves comparing early and late pancreatic cancer (early pancreatic cancer + late pancreatic cancer) with all control subjects, including healthy controls and patients with chronic pancreatitis (healthy control + chronic pancreatitis); B: Receiver operating characteristic curves comparing early pancreatic cancer with chronic pancreatitis. Areas under the curve with 95% confidence intervals are shown for both the original dataset and internal validation. Comparisons of areas under the curves between S100A6 and the other biomarkers were performed using DeLong’s test. ^aP < 0.05. CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; EPC: Early pancreatic cancer; LPC: Late pancreatic cancer; H: Healthy control; CP: Chronic pancreatitis; AUC: Areas under the curve.