Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer

doi:10.3748/wjg.v32.i21.116527

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 7, 2026; 32(21): 116527
Published online Jun 7, 2026. doi: 10.3748/wjg.v32.i21.116527

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Figure 5 Effects of Yin Yang 1-associated protein 1 overexpression and knockdown in MKN45 cells on key cancer-related markers and cellular behaviors were tested. A and B: The data on mRNA and protein expression levels of Yin Yang 1-associated protein 1 (YY1AP1), p21, c-myc, and snail; C and D: EdU experiments showed that overexpressing YY1AP1 can significantly promote gastric cancer cell proliferation while silencing YY1AP1 exerts opposite effects, which had also been confirmed by MTT assays; E: Transwell assays showed the migration and invasion impacts of YY1AP1 in gastric cancer cells. YY1AP1: Yin Yang 1-associated protein 1; siRNA: Small interfering RNA; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.

Citation: Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, Fu ZW, Huang JH, Ren ZY. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026; 32(21): 116527
URL: https://www.wjgnet.com/1007-9327/full/v32/i21/116527.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i21.116527

Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, Fu ZW, Huang JH, Ren ZY. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026; 32(21): 116527 [DOI: 10.3748/wjg.v32.i21.116527]

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