Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer

Figure 4 Kaplan-Meier survival analyses stratified by clinicopathological features based on Yin Yang 1-associated protein 1 expression. A: High Yin Yang 1-associated protein 1 (YY1AP1) expression showed a trend toward shorter survival, though not statistically significant (P = 0.052) in gastric cancers with intestinal type; B: High YY1AP1 expression was associated with significantly worse survival (P = 0.026) in gastric cancers with diffuse type; C: No significant survival difference between high and low YY1AP1 expression groups (P = 0.17) in female patients; D: High YY1AP1 expression was linked to shorter survival (P = 0.005) in male patients; E: High YY1AP1 expression correlated with poorer outcomes (P = 0.035) in the gastric cancer patients who only accepted surgery treatment; F: No significant survival difference based on YY1AP1 expression (P = 0.093) for those patients who underwent 5-fluorouracil based adjuvant therapy after surgical treatment; G: A marginal survival trend was noted for high expression (P = 0.056), however without significance those patients who underwent other adjuvant therapy after surgical treatment; H: In human epidermal growth factor receptor 2-negative patients, high YY1AP1 expression was significantly associated with worse survival (P = 0.0079); I: In human epidermal growth factor receptor 2-positive patients, no significant difference in survival outcomes (P = 0.34). Data were extracted from GSE14210, GSE15459, GSE22377, GSE29272, GSE51105, and GSE62254. YY1AP1: Yin Yang 1-associated protein 1; 5-Fu: 5-fluorouracil; HER2: Human epidermal growth factor receptor 2.