Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer

doi:10.3748/wjg.v32.i21.116527

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 7, 2026; 32(21): 116527
Published online Jun 7, 2026. doi: 10.3748/wjg.v32.i21.116527

Table 2 Kaplan-Meier cancer-specific survival analysis, mean ± SD

Clinicopathologic features	OS months	5-year OS, %	P value
Age, years
≤ 55	63.9 ± 3.4	55.6	0.457
> 55	60.3 ± 2.4	64.6
Gender
Female	58.7 ± 3.5	53.9	0.621
Male	62.7 ± 2.5	64.4
Localization
Upper	48.2 ± 4.0	33.1	0.229
Middle	64.3 ± 2.8	66.8
Lower	60.1 ± 3.0	58.9
Tumor size, cm
≤ 5.0	65.0 ± 2.5	64.1	0.172
> 5.0	57.6 ± 3.0	57.5
T stage
T1-T2	68.0 ± 2.7	74.8	0.018
T3-T4	56.6 ± 2.8	49.0
Differentiation
Well	68.0 ± 5.3	81.8	0.002
Moderate	66.3 ± 2.5	72.1
Poor	51.9 ± 2.8	42.3
TNM stage
I-II	67.6 ± 2.5	65.4	0.013
III-IV	56.0 ± 2.9	57.1
YY1AP1 level
Low	67.4 ± 2.4	72.7	0.014
High	56.0 ± 3.0	48.4

OS: Overall survival; YY1AP1: Yin Yang 1-associated protein 1; TNM: Tumor-node-metastasis.

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Citation: Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, Fu ZW, Huang JH, Ren ZY. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026; 32(21): 116527
URL: https://www.wjgnet.com/1007-9327/full/v32/i21/116527.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i21.116527

Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, Fu ZW, Huang JH, Ren ZY. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026; 32(21): 116527 [DOI: 10.3748/wjg.v32.i21.116527]

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