Textbook oncologic outcomes following pancreatoduodenectomy in patients with pancreatic adenocarcinoma: A high-volume center study

Table 3 Univariate and multivariable logistic regression analysis of textbook oncologic outcome achievement in the laparoscopic pancreaticoduodenectomy cohort

Variables	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Sex (male)	0.74 (0.36-1.51)	0.412
Age (≥ 60 years)	0.63 (0.31-1.29)	0.210
BMI (kg/m2)
≥ 18.5, < 24	Reference
< 18.5	0.58 (0.11-2.94)	0.510
≥ 24	0.77 (0.31-1.92)	0.579
Diabetes	1.64 (0.58-4.63)	0.350
Cardiovascular disease	0.83 (0.35-1.97)	0.666
ASA
I	Reference
II	0.30 (0.07-1.20)	0.089
III	0.43 (0.10-1.84)	0.254
Serum albumin (≥ 37.95 g/L)	3.03 (1.38-6.65)	0.006a	2.65 (1.00-7.00)	0.050
PLR (≥ 174.2)	0.59 (0.28-1.21)	0.150
NLR (≥ 1.61)	0.34 (0.14-0.82)	0.016a	0.42 (0.14-1.26)	0.121
PNI (≥ 48.83)	3.09 (1.36-7.02)	0.007a	1.91 (0.67-5.51)	0.228
CONUT score
≤ 3	Reference
≥ 4	0.55 (0.23-1.32)	0.181
SII (≥ 484.09)	0.64 (0.31-1.30)	0.217
NPS (≥ 3)	0.81 (0.40-1.65)	0.558
ALT (≥ 254.5 U/L)	2.48 (1.15-5.33)	0.020a	2.28 (0.88-5.89)	0.090
AST (≥ 133.5 U/L)	1.67 (0.81-3.45)	0.162
ALP (≥ 105.5 U/L)	0.65 (0.29-1.50)	0.314
γ-GT (≥ 657 U/L)	1.60 (0.77-3.32)	0.204
TBIL (≥ 63.2 μmol/L)	0.57 (0.28-1.17)	0.126
DBIL (≥ 35.15 μmol/L)	0.50 (0.24-1.03)	0.059
Serum total cholesterol level (≥ 5.59 mmol/L)	2.41 (1.07-5.42)	0.033a	2.29 (0.84-6.29)	0.107
CA19-9 (≥ 37 U/mL)	0.70 (0.32-1.57)	0.389
CEA (≥ 5 ng/mL)	1.89 (0.81-4.41)	0.143
Preoperative biliary drainage	0.77 (0.38-1.58)	0.481
Tumor size (cm)	0.98 (0.70-1.38)	0.910
T stage
T1	Reference
T2	1.02 (0.47-2.21)	0.963
T3 and T4	0.54 (0.10-2.86)	0.465
N stage
N0	Reference
N1	1.08 (0.48-2.43)	0.861
N2	1.00 (0.28-3.50)	0.995
M stage
M0	Reference
M1	2.23 (0.14-36.43)	0.574
Degree of tumor differentiation	Reference
High and moderate	Reference
Low and undifferentiated	1.40 (0.67-2.90)	0.371
Clavien-Dindo classification
I	Reference
II and above	0.18 (0.06-0.49)	< 0.001a	0.22 (0.07-0.68)	0.008a
Length of stay (days)	0.91 (0.86-0.97)	0.002a	0.94 (0.88-1.00)	0.048a

^aP < 0.05.

OR: Odds ratio; CI: Confidence interval; ASA: American Society of Anesthesiologists; BMI: Body mass index; PLR: Platelet to lymphocyte ratio; NLR: Neutrophil to lymphocyte ratio; PNI: Prognostic nutritional index; CONUT: Controlling nutritional status; SII: Systemic immune inflammation index; NPS: Naples prognostic score; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; γ-GT: γ-glutamyl transferase; TBIL: Total bilirubin; DBIL: Direct bilirubin; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen.