Textbook oncologic outcomes following pancreatoduodenectomy in patients with pancreatic adenocarcinoma: A high-volume center study

doi:10.3748/wjg.v32.i20.119062

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 28, 2026; 32(20): 119062
Published online May 28, 2026. doi: 10.3748/wjg.v32.i20.119062

Table 2 Perioperative outcomes and survival data of open pancreaticoduodenectomy and laparoscopic pancreaticoduodenectomy, n (%)

Characteristic	LPD (n = 144)	OPD (n = 144)	Total (n = 288)	P value
Preoperative biliary drainage	83 (57.6)	80 (55.6)	163 (56.6)	0.721
Tumor size (cm), median (IQR)	2.8 (2.0, 3.2)	3.0 (2.0, 3.2)	3.0 (2.0, 3.2)	0.766
Degree of tumor differentiation
High	7 (4.9)	10 (6.9)	17 (5.9)	0.889
Low	49 (34)	50 (34.7)	99 (34.4)
Moderate	87 (60.4)	83 (57.6)	170 (59)
Undifferentiated	1 (0.7)	1 (0.7)	2 (0.7)
T stage
T1	44 (30.6)	39 (27.1)	83 (28.8)	0.772
T2	90 (62.5)	94 (65.3)	184 (63.9)
T3	8 (5.6)	7 (4.9)	15 (5.2)
T4	2 (1.4)	4 (2.8)	6 (2.1)
N stage
N0	94 (65.3)	91 (63.2)	185 (64.2)	0.364
N1	37 (25.7)	45 (31.2)	82 (28.5)
N2	13 (9)	8 (5.6)	21 (7.3)
M stage
M0	142 (98.6)	142 (98.6)	284 (98.6)	1.000
M1	2 (1.4)	2 (1.4)	4 (1.4)
Operation time (min), median (IQR)	330.0 (280.0, 400.5)	370.0 (283.5, 440.0)	350.0 (281.5, 429.5)	0.216
Bile leakage	9 (6.2)	4 (2.8)	13 (4.5)	0.156
Postoperative abdominal infection	10 (6.9)	8 (5.6)	18 (6.2)	0.626
POPF	23 (16)	48 (33.3)	71 (24.7)	< 0.001^a
DGE	41 (28.5)	110 (76.4)	151 (52.4)	< 0.001^a
PPH	16 (11.1)	12 (8.3)	28 (9.7)	0.426
Gastrointestinal fistula	0 (0)	2 (1.4)	2 (0.7)	0.156
Liver failure	1 (0.7)	3 (2.1)	4 (1.4)	0.314
Kidney failure	0 (0)	1 (0.7)	1 (0.3)	0.316
Lung infection	0 (0)	5 (3.5)	5 (1.7)	0.024^a
Clavien-Dindo classification
I	98 (68.1)	64 (44.4)	162 (56.2)	0.225
II	24 (16.7)	62 (43.1)	86 (29.9)
III	3 (2.1)	4 (2.8)	7 (2.4)
IV	15 (10.4)	13 (9)	28 (9.7)
V	4 (2.8)	1 (0.7)	5 (1.7)
Length of stay (days), median (IQR)	20.0 (16.0, 25.5)	22.0 (16.0, 27.0)	21.0 (16.0, 26.0)	0.052
Overall survival time (months), median (IQR)	15.4 (9.0, 24.2)	14.5 (8.1, 22.0)	15.1 (8.8, 23.2)	0.134
TOO	45 (31.2)	33 (22.9)	78 (27.1)	0.112

^aP < 0.05.

OPD: Open pancreaticoduodenectomy; LPD: Laparoscopic pancreaticoduodenectomy; IQR: Interquartile range; POPF: Postoperative pancreatic fistula; DGE: Delayed gastric emptying; PPH: Postpancreatectomy hemorrhage; TOO: Textbook oncologic outcome.

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Citation: Zhang JZ, Guo XY, Zhang ZW, Zhu DS, Zhang Z, Zheng H, Guo T, Yu YH, Huang XR. Textbook oncologic outcomes following pancreatoduodenectomy in patients with pancreatic adenocarcinoma: A high-volume center study. World J Gastroenterol 2026; 32(20): 119062
URL: https://www.wjgnet.com/1007-9327/full/v32/i20/119062.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i20.119062

Zhang JZ, Guo XY, Zhang ZW, Zhu DS, Zhang Z, Zheng H, Guo T, Yu YH, Huang XR. Textbook oncologic outcomes following pancreatoduodenectomy in patients with pancreatic adenocarcinoma: A high-volume center study. World J Gastroenterol 2026; 32(20): 119062 [DOI: 10.3748/wjg.v32.i20.119062]

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