Noninvasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan

Table 6 Clinical utilities of the fibrosis-4 and type IV collagen 7S (radioimmunoassay) for the diagnosis of fibrosis stages 2 and 3 or higher[17]

		Cutoff value	PPV	NPV	Sensitivity	Specificity	FN	FP
FIB-4 index	Low	1.30	0.257	0.962	0.892	0.513	0.108	0.487
	High	2.67	0.382	0.093	0.547	0.833	0.453	0.167
COL4-7S (ng/mL), F0-1 vs F2-4)	Low	3.8	0.541	0.842	0.902	0.405	0.098	0.595
	High	6.0	0.775	0.676	0.446	0.900	0.554	0.100
FIB-4 and COL4-7S		1.3 and 3.8	0.690	0.792	0.752	0.737	0.248	0.263
COL4-7S, F0-2 vs F3-4	Low	4.8	0.315	0.969	0.892	0.634	0.108	0.366
	High	6.8	0.530	0.081	0.576	0.904	0.424	0.096
FIB-4 and COL4-7S (ng/mL)		1.3 and 4.8	0.366	0.953	0.806	0.737	0.194	0.263
F0-1 vs F2-4		1.3 and 4.3	0.706	0.787	0.730	0.766	0.270	0.234
F0-2 vs F3-4		1.3 and 4.3	0.307	0.963	0.871	0.630	0.129	0.370

Cutoff values were calculated with 90% sensitivity and 90% specificity. Type IV collagen 7S scores were measured using the radioimmunoassay method. FIB-4: Fibrosis-4; COL4-7S: Type IV collagen 7S; PPV: Positive predictive value; NPV: Negative predictive value; FN: False negative rate; FP: False positive rate.