Noninvasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan

doi:10.3748/wjg.v32.i2.114097

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World Journal of Gastroenterology

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1007-9327

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Evidence Review

World J Gastroenterol. Jan 14, 2026; 32(2): 114097
Published online Jan 14, 2026. doi: 10.3748/wjg.v32.i2.114097

Table 2 Cutoff values for each noninvasive test according to liver fibrosis stage

	F2	F3	F4
ELF score	10.1	11.1	11.5
ELF score¹ (for prediction of event)	-	9.8	11.3
M2BPGi (C.O.I./AU/mL)	1.15	0.99	1.71
COL4-7S (ng/mL)	3.8	4.8	6.6
VCTE¹ (kPa)	-	Rule-in: 12 kPa. Rule-out: 8 kPa	Rule-in: 20 kPa. Rule-out: 8 kPa
MRE (kPa)	3.14	3.53	4.45

¹According to guidelines from the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver-European Association for the Study of Diabetes-European Association for the Study of Obesity.

ELF: Enhanced liver fibrosis; M2BPGi: Mac-2-binding protein glycosylation isomer; C.O.I.: Cutoff index; COL4-7S: Type IV collagen 7S; VCTE: Vibration-controlled transient elastography; MRE: Magnetic resonance elastography.

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Citation: Kamada Y, Sumida Y, Takahashi H, Ishiba H, Kawanaka M, Tada T, Yoneda M, Imajo K, Seko Y, Fujii H, Nakajima A. Noninvasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan. World J Gastroenterol 2026; 32(2): 114097
URL: https://www.wjgnet.com/1007-9327/full/v32/i2/114097.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i2.114097

Kamada Y, Sumida Y, Takahashi H, Ishiba H, Kawanaka M, Tada T, Yoneda M, Imajo K, Seko Y, Fujii H, Nakajima A. Noninvasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan. World J Gastroenterol 2026; 32(2): 114097 [PMID: 41551835 DOI: 10.3748/wjg.v32.i2.114097]

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