Noninvasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan

doi:10.3748/wjg.v32.i2.114097

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Evidence Review

World J Gastroenterol. Jan 14, 2026; 32(2): 114097
Published online Jan 14, 2026. doi: 10.3748/wjg.v32.i2.114097

Table 1 Noninvasive tests for the diagnosis of liver fibrosis and activity used in Japan

Classification of NITs		Name of NITs
Scoring system		FIB-4 index
Scoring system		NAFLD fibrosis score
Blood biomarkers	Liver-specific fibrosis markers	ELF test
		COL4-7S
		M2BPGi
		ATX
		HA
	Hepatocyte apoptosis marker	CK-18F (M30)

NITs: Noninvasive tests; FIB-4: Fibrosis-4; NAFLD: Non-alcoholic fatty liver disease; ELF: Enhanced liver fibrosis; COL4-7S: Type IV collagen 7S; M2BPGi: Mac-2-binding protein glycosylation isomer; ATX: Autotaxin; HA: Hyaluronic acid; CK-18F: Cytokeratin 18 fragment.

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Citation: Kamada Y, Sumida Y, Takahashi H, Ishiba H, Kawanaka M, Tada T, Yoneda M, Imajo K, Seko Y, Fujii H, Nakajima A. Noninvasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan. World J Gastroenterol 2026; 32(2): 114097
URL: https://www.wjgnet.com/1007-9327/full/v32/i2/114097.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i2.114097

Kamada Y, Sumida Y, Takahashi H, Ishiba H, Kawanaka M, Tada T, Yoneda M, Imajo K, Seko Y, Fujii H, Nakajima A. Noninvasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan. World J Gastroenterol 2026; 32(2): 114097 [PMID: 41551835 DOI: 10.3748/wjg.v32.i2.114097]

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