Cedrol ameliorates ulcerative colitis via myeloid differentiation factor 2-mediated inflammation suppression, with barrier restoration and microbiota modulation

Figure 3 Cedrol re-established intestinal barrier integrity in dextran sulfate sodium-induced colitis. A: Characteristic alcian blue periodic acid-Schiff staining (× 100) and histogram of stained regions; B-D: Representative immunohistochemistry images (× 100) and statistical analysis of the average optical density for zonula occludens 1 (B), occludin (C), and claudin 1 (D). Data are expressed as mean ± SD (n = 6). ^aP < 0.05. ^bP < 0.01. ^dP < 0.0001. CE: Cedrol; DSS: Dextran sulfate sodium; AB-PAS: Alcian blue periodic acid-Schiff staining; AOD: Average optical density; ZO-1: Zonula occludens 1.