Association of FADS2 polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn’s disease

doi:10.3748/wjg.v32.i2.112132

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 32, Issue 2

This Article

(41)

(43)

(0)

(1)

(654)

(1)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastroenterol. Jan 14, 2026; 32(2): 112132
Published online Jan 14, 2026. doi: 10.3748/wjg.v32.i2.112132

Table 2 Serum and erythrocyte membrane fatty acid composition in Crohn’s disease patients, n = 52

Plasma	median ± SD	RBC	median ± SD
SFA (%)		SFA (%)
C16:0 PA	24.4 ± 2.05	C16:0 PA	23.1 ± 1.94
C18:0 SA	6.97 ± 0.83	C18:0 SA	17.3 ± 0.86
C20:0 AdA	0.27 ± 0.05	C20:0 AdA	0.42 ± 0.05
C24:0 LgA	0.52 ± 0.14	C24:0 LgA	5.89 ± 0.53
n-9 (%)		n-9 (%)
C16:1 PtA	2.82 ± 1.61	C16:1 PtA	0.32 ± 0.17
C18:1 OA	23.3 ± 4.05	C18:1 OA	12.4 ± 1.07
C20:1 EA	0.15 ± 0.05	C20:1 EA	0.21 ± 0.04
C22:1 EcA	0.02 ± 0.03	C22:1 EcA	0.09 ± 0.02
C24:1 NA	1.33 ± 0.40	C24:1 NA	6.25 ± 0.57
n-3 (%)		n-3 (%)
C18:3 ALA	0.79 ± 0.82	C18:3 ALA	0.09 ± 0.06
C20:5 EPA	1.71 ± 1.69	C20:5 EPA	1.08 ± 0.97
C22:5 DPA	0.60 ± 0.29	C22:5 DPA	1.82 ± 0.56
C22:6 DHA	3.74 ± 1.53	C22:6 DHA	6.31 ± 2.02
n-6 (%)		n-6 (%)
C18:2 LA	22.9 ± 6.81	C18:2 LA	6.86 ± 1.54
C20:2 EDA	0.20 ± 0.04	C20:2 EDA	0.22 ± 0.04
C18:3 GLA	0.46 ± 0.43	C18:3 GLA	0.55 ± 0.03
C20:3 DGLA	1.33 ± 0.43	C20:3 DGLA	1.39 ± 0.29
C20:4 AA	6.54 ± 1.75	C20:4 AA	12.0 ± 1.67
C22:4 DTA	0.21 ± 0.09	C22:4 DTA	2.05 ± 0.61
d5di: AA/DGLA	5.26 ± 1.78	d5di: AA/DGLA	8.95 ± 1.88
rd.d6di: GLA/LA	0.03 ± 0.05	rd.d6di: GLA/LA	0.01 ± 0.01

%: Percentage weight of each fatty acid. AA: Arachidonic acid; AdA: Arachidic acid; ALA: Α-linolenic acid; rd.d6di: Redefined δ6 desaturase index; d5di: Δ5 desaturase index; DGLA: Dihomo-γ-linolenic acid; DHA: Docosahexaenoic acid; DPA: Docosapentaenoic acid; DTA: Docosatetraenoic acid; EcA: Erucic acid; EDA: Eicosadienoic acid; EPA: Eicosapentaenoic acid; GLA: γ-linolenic acid; LA: Linoleic acid; LgA: Lignoceric acid; MA: Myristic acid; NA: Nervonic acid; OA: Oleic acid; PA: Palmitic acid; PtA: Palmitoleic acid; SA: Stearic acid; SFA: Saturated fatty acid.

Full Size Table

Citation: Matsuzawa H, Ito Z, Uchiyama K, Motoi Y, Ohtaki Y, Iwashita Y, Suzuki S, Nakada T, Koido S, Kojima K, Murohashi K, Saruta M, Ohkusa T, Kubota T. Association of FADS2 polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn’s disease. World J Gastroenterol 2026; 32(2): 112132
URL: https://www.wjgnet.com/1007-9327/full/v32/i2/112132.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i2.112132

Matsuzawa H, Ito Z, Uchiyama K, Motoi Y, Ohtaki Y, Iwashita Y, Suzuki S, Nakada T, Koido S, Kojima K, Murohashi K, Saruta M, Ohkusa T, Kubota T. Association of FADS2 polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn’s disease. World J Gastroenterol 2026; 32(2): 112132 [PMID: 41551830 DOI: 10.3748/wjg.v32.i2.112132]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.