Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy

doi:10.3748/wjg.v32.i19.116513

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 32, Issue 19

This Article

(32)

(33)

(0)

(9)

(1)

(615)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 21, 2026; 32(19): 116513
Published online May 21, 2026. doi: 10.3748/wjg.v32.i19.116513

Table 2 Cohort balancing characteristics of patients before and after propensity score matching

Perioperative vs postoperative treatment	Before PSM		Statistical volume	P value	After PSM (3:1)		Statistical volume	P value
Perioperative vs postoperative treatment	Perioperative treatment (n = 532)	Postoperative treatment (n = 110)	Statistical volume	P value	Perioperative treatment (n = 330)	Postoperative treatment (n = 110)	Statistical volume	P value
Age, years, median (IQR)	54.0 (47.0-62.0)	54.0 (47.0-62.8)	W = 28311.0	0.592	54.0 (47.0-62.0)	54.0 (47.0-62.8)	W = 17514.5	0.582
Male sex	280 (52.6)	70 (63.6)	χ² = 4.452	0.035	216 (65.5)	70 (63.6)	χ² = 0.120	0.729
ALT, median (IQR)	24.0 (17.0-33.0)	31.00 (20.3-35.0)	W = 23603.5	0.001	31.0 (20.0-36.0)	31.0 (20.3-35.0)	W = 18114.5	0.976
Extent of resection			χ² = 0.068	0.794			χ² = 0.003	0.953
Major resection	351 (66.0)	74 (67.3)			223 (67.6)	74 (67.3)
Minor resection	181 (34.0)	36 (32.7)			107 (32.4)	36 (32.7)
Prophylaxis vs no prophylaxis	Before PSM		Statistical volume	P value	After PSM (1:1)		Statistical volume	P value
	Prophylaxis (n = 876)	No prophylaxis (n = 835)	Statistical volume	P value	Prophylaxis (n = 680)	No prophylaxis (n = 680)	Statistical volume	P value
Age, years, median (IQR)	53.5 (46.0-62.0)	54.0 (46.0-62.0)	W = 359007.5	0.510	54.0 (46.8-62.0)	53.0 (45.0-62.0)	W = 233831.0	0.716
Male sex	330 (37.7)	451 (54.0)	χ² = 46.01	< 0.001	319 (46.9)	321 (47.2)	χ² = 0.012	0.913
ALT, median (IQR)	23.0 (16.0-33.0)	24.00 (16.0-33.0)	W = 356161.5	0.349	23.0 (15.0-33.0)	24.0 (16.0-33.0)	W = 228588.5	0.718
Extent of resection			χ² = 33.227	< 0.001			χ² = 1.196	0.274
Major resection	423 (48.3)	519 (62.2)			373 (54.9)	393 (57.8)
Minor resection	453 (51.7)	316 (37.8)			307 (45.2)	287 (42.2)
Treatment with magnesium isoglycyrrhizinate plus other liver protectants vs other liver protectants only	Before PSM		Statistical volume	P value	After PSM (1:3)		Statistical volume	P value
	MgIG plus other liver protectants (n = 110)	Other liver protectants (n = 536)	Statistical volume	P value	MgIG plus other liver protectants (n = 110)	Other liver protectants (n = 330)	Statistical volume	P value
Age, years, median (IQR)	54.0 (47.0-62.8)	54.0 (47.0-62.0)	W = 28753.0	0.684	54.0 (47.0-62.8)	54.0 (48.0-62.0)	W = 17948.0	0.861
Male sex	70 (63.6)	342 (63.8)	χ² = 0.001	0.973	70 (63.6)	192 (58.2)	χ² = 1.019	0.313
ALT, median (IQR)	204.5 (141.3-428.3)	216.5 (116.8-384.0)	W = 28763.5	0.688			W = 17186.0	0.404
Extent of resection			χ² = 1.264	0.261			χ² = 0.165	0.685
Major resection	74 (67.3)	389 (72.6)			74 (67.3)	215 (65.2)
Minor resection	36 (32.7)	147 (27.4)			36 (32.7)	115 (34.9)

Sum may not equal 100% because of rounding. Major liver resection indicates resection of at least half of the liver volume and minor liver resection indicates resection of one fourth or less of the liver volume. ALT: Alanine aminotransferase; PSM: Propensity score matching; MgIG: Magnesium isoglycyrrhizinate; IQR: Interquartile range.

Full Size Table

Citation: Xie ZQ, Wei JX, Zhong JY, Luo X, Zhuang HK, Ma XW, Wang QB, Tan WL, Wang BK, Chen YJ, Li CJ, Shang CZ. Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy. World J Gastroenterol 2026; 32(19): 116513
URL: https://www.wjgnet.com/1007-9327/full/v32/i19/116513.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i19.116513

Xie ZQ, Wei JX, Zhong JY, Luo X, Zhuang HK, Ma XW, Wang QB, Tan WL, Wang BK, Chen YJ, Li CJ, Shang CZ. Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy. World J Gastroenterol 2026; 32(19): 116513 [DOI: 10.3748/wjg.v32.i19.116513]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.