Serca2 deletion in the mouse adult Bmi1+ compartment induces a lethal phenotype involving a severe gastric dysfunction

Figure 1 Impact of conditional Serca2 deletion on survival, blood biochemistry, weight evolution and glucose absorption. A and B: Survival curves of homozygous (homo) (A) and heterozygous (hetero) (B). DSerca2^Bmi1homo mice compared with their respective controls (n = 15; each; age-matched animals); C and D: Complete blood count tests of DSerca2^Bmi1homo [10 days post-tamoxifen (Tx)] and control mice (n = 3 each; age-matched animals); E: Blood biochemical analysis of DSerca2^Bmi1homo (10 days post-Tx) and control mice (n = 3 each; age-matched animals); F and G: Weight evolution of DSerca2^Bmi1homo mice (F) and DSerca2^Bmi1hetero mice (G), for 12 days or 6 weeks, respectively (n = 9 each; age-matched animals); H: Glucose tolerance test (10 days post-Tx) comparing DSerca2^Bmi1homo and controls (n = 3 each; age-matched animals). Data are expressed as mean ± SD. ^aP < 0.05. ^bP < 0.01. Homo: Homozygous; hetero: Heterozygous; RBC: Red blood cell; HCT: Hematocrit; HGB: Hotal hemoglobin; MCV: Mean red blood cell size; MCH: Mean corpuscular hemoglobin; MCHC: Mean corpuscular hemoglobin are indicated in C; WBC: White blood cells; PLT: Platelet counts; MPV: Mean platelet volume; NEUT: Neutrophils; MONO: Monocytes; LYM: Lymphocytes and included in D; Tx: Tamoxifen.