Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors

doi:10.3748/wjg.v32.i18.118416

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 14, 2026; 32(18): 118416
Published online May 14, 2026. doi: 10.3748/wjg.v32.i18.118416

Table 4 Receiver operating characteristic analysis of factors influencing poor prognosis

Variable	Best_threshold	Sensitivities	Specificities	AUC	Youden_index	F1_score
BCLC stage	0.5	0.778	0.357	0.567	0.135	0.615
Maximum tumor diameter (cm)	9.165	0.444	0.825	0.657	0.269	0.539
AFP (ng/mL)	673.855	0.694	0.746	0.778	0.44	0.698
NLR	3.165	0.759	0.69	0.785	0.449	0.716
AST (U/L)	57.64	0.398	0.778	0.586	0.176	0.48
Total bilirubin (μmol/L)	19.57	0.583	0.603	0.598	0.186	0.57
Albumin (g/L)	37.695	0.611	0.587	0.607	0.198	0.375

BCLC: Barcelona Clinic Liver Cancer; AFP: Alpha fetoprotein; NLR: Neutrophil-to-lymphocyte ratio; AST: Aspartate aminotransferase; AUC: Area under the curve.

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Citation: Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; 32(18): 118416
URL: https://www.wjgnet.com/1007-9327/full/v32/i18/118416.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i18.118416