Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors

doi:10.3748/wjg.v32.i18.118416

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 14, 2026; 32(18): 118416
Published online May 14, 2026. doi: 10.3748/wjg.v32.i18.118416

Table 1 Comparison of baseline information between patients with good prognosis and poor prognosis, n (%)/mean ± SD

Variable	Good prognosis group (n = 126)	Poor prognosis group (n = 108)	t/χ²	P value
Gender			0.035	0.851
Male	105 (83.33)	89 (82.41)
Female	21 (16.67)	19 (17.59)
Age (years)	56.81 ± 5.15	57.49 ± 5.02	1.020	0.309
BMI (kg/m²)	22.46 ± 1.47	22.15 ± 1.59	1.536	0.126
History of smoking	58 (46.03)	55 (50.93)	0.558	0.455
History of alcohol consumption	52 (41.27)	49 (45.37)	0.399	0.528
Etiology			0.250	0.883
Hepatitis B	113 (89.68)	98 (90.74)
Hepatitis C	5 (3.97)	3 (2.78)
Others	8 (6.35)	7 (6.48)
BCLC stage			5.661	0.017
B	46 (36.51)	24 (22.22)
C	80 (63.49)	84 (77.78)
Child-Pugh grade			3.009	0.083
A	104 (82.54)	79 (73.15)
B	22 (17.46)	29 (26.85)
ECOG PS score			3.951	0.047
0	87 (69.05)	61 (56.48)
1	39 (30.95)	47 (43.52)
Maximum tumor diameter (cm)	7.61 ± 1.93	8.79 ± 2.21	4.350	< 0.001
Macrovascular invasion	57 (45.24)	67 (62.04)	6.588	0.010
Extrahepatic spread	81 (64.29)	84 (77.78)	5.091	0.024

BMI: Body mass index; BCLC: Barcelona Clinic Liver Cancer; ECOG PS: Eastern Cooperative Oncology Group Performance Status.

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Citation: Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; 32(18): 118416
URL: https://www.wjgnet.com/1007-9327/full/v32/i18/118416.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i18.118416