Longitudinal changes in the gut microbiota of Vietnamese patients with colorectal cancer undergoing surgery and chemotherapy

Figure 4 Heatmap showing the Spearman’s rank correlations between amplicon sequence variant abundance and serum biochemical markers. Spearman’s ρ values were computed for each amplicon sequence variant (ASV) in relation to each biochemical marker. Multiple testing was adjusted using the Benjamini-Hochberg method, and only ASVs or markers with adjusted P values < 0.05 are displayed. Hierarchical clustering of ASVs was performed using the Euclidean distance metric. ^aAdjusted P < 0.05. ASVs were labeled with genus (g_), or family (f_), or order (o_) when the genus-level classification was unavailable. ASV: Amplicon sequence variant; GOT: Glutamic oxaloacetic transaminase; GPT: Glutamic pyruvic transaminase; CEA: Carcinoembryonic antigen.