Longitudinal changes in the gut microbiota of Vietnamese patients with colorectal cancer undergoing surgery and chemotherapy

doi:10.3748/wjg.v32.i18.118267

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 14, 2026; 32(18): 118267
Published online May 14, 2026. doi: 10.3748/wjg.v32.i18.118267

Table 1 Clinical characteristics of patients with colorectal cancer, n (%)

Characteristic	Categories	Number of patients
Age at diagnosis (years): 64.3 ± 8 years	50-60	10 (32.3)
	60-70	10 (32.3)
	70-80	11 (35.5)
BMI	Normal weight	25 (80.6)
	Overweight	4 (12.9)
	Underweight	2 (6.5)
Sex	Female	11 (35.5)
Sex	Male	20 (64.5)
Comorbidity	Type 2 diabetes	6 (19.4)
Comorbidity	Hypertension	7 (22.6)
Family history of CRC		3 (9.7)
Tumor size (cm)	2-5	17 (54.8)
Tumor size (cm)	5-10	14 (45.2)
TNM stage	Stage II	9 (29)
	Stage III	18 (58.1)
	Stage IV	4 (12.9)
Tumor location	Left colon	14 (45.2)
	Right colon	9 (29)
	Transverse colon	2 (6.5)
	Rectum	6 (19.4)
Metastasis	Yes	6 (19.4)
Metastasis	No	25 (80.6)
Treatment regimen	Single agent (5-FU)	13 (41.9)
	Capecitabine	8 (25.8)
	Ufur	4 (12.9)
	TS1	1 (3.2)
	Combination therapy (≥ 2 agents including 5-FU and oxaliplatin)	18 (58.1)
	mFOLFOX6	11 (35.5)
	XELOX	5 (16.1)
	B-mFOLFOX6	2 (6.5)
Therapy response	Complete response	25 (80.6)
	Partial response	3 (9.7)
	Disease progression	3 (9.7)

BMI: Body mass index; CRC: Colorectal cancer; 5-FU: 5-fluorouracil; TNM: Tumor, node and metastasis.

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Citation: Le HTT, Le HX, Huyen DT, Tran TA, Quyen DV, Song LH, Tran TV, Thas O, Nhung PTT, Tran TTT. Longitudinal changes in the gut microbiota of Vietnamese patients with colorectal cancer undergoing surgery and chemotherapy. World J Gastroenterol 2026; 32(18): 118267
URL: https://www.wjgnet.com/1007-9327/full/v32/i18/118267.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i18.118267

Le HTT, Le HX, Huyen DT, Tran TA, Quyen DV, Song LH, Tran TV, Thas O, Nhung PTT, Tran TTT. Longitudinal changes in the gut microbiota of Vietnamese patients with colorectal cancer undergoing surgery and chemotherapy. World J Gastroenterol 2026; 32(18): 118267 [DOI: 10.3748/wjg.v32.i18.118267]

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