Outcomes of pediatric liver transplant recipients who reach adulthood: Current perspectives and unmet needs

Table 1 Predictors of ideal long-term outcome after pediatric liver transplantation

Variables associated with ideal outcome at 10 years follow-up[9]	Prevalence1 (%)	Variables associated with AYA-ideal outcome at long term follow-up[8]	Prevalence (%)
Graft related issues
No re-transplantation	88	No late re-transplantation2	76.7
No chronic rejection	91	No chronic rejection	93.3
Normal liver enzymes (alanine aminotransferase)	89	Normal liver enzymes (alanine aminotransferase)	66.7
Normal liver enzymes (gamma-glutamyl transpeptidase)	85	Normal liver enzymes (gamma glutamyl transpeptidase)	74.2
Normal liver function (albumin)	98	Normal liver function (albumin)	87.5
Normal liver function (total bilirubin)	99
Immunosuppression-induced issues
No post-transplant lymphoproliferative disease	94	No malignancy2	95
No renal dysfunction (i.e., GFR < 90 mL/minute/1.73 m2)	91	No renal dysfunction (i.e., GFR < 90 mL/minute/1.73 m2)	61.7
Acceptable linear growth	93	No arterial hypertension2	68.3
No diabetes	99	No diabetes	99.2
Additional medications
No ongoing use of prednisone	81	No antiseizure medication	97.5
No use of antihypertensive agents	87	No treatment with steroids	80.8
No use of antiseizure medication	100

¹Prevalence of ideal outcome has been calculated from patients with all available data (n = 106/167; of these, 53 fulfilled criteria of ideal outcome since they fulfilled all the above-mentioned items).

²Differences between the two scores.

GFR: Glomerular filtration rate; AYA: Adolescent and young adult.