LGALS1 drives chemoresistance in esophageal squamous cell carcinoma by modulating epithelial-mesenchymal transition and tumor immunity

Figure 3 Neoadjuvant chemoradiotherapy facilitated CD8+ T cell activation. A: UMAP visualization displaying 9 distinct clusters comprising 9968 T/natural killer cells; B: Heatmap illustrating marker gene expression across T cell subsets; C: Comparative analysis of T-cell functional scores; D: Temporal trajectory analysis of the entire CD8+ T cell population; E: Positioning of CD8+ T cell subtypes along the cellular developmental trajectory; F: Distinct groups along the cellular developmental trajectory; G: CytoTRACE score distribution throughout cellular developmental pathways; H: UMAP representation of CytoTRACE score distribution; I: Comparative differentiation levels among various CD8+ T cell subsets. ^dP < 0.0001. IFN: Interferon; Neo: Neoadjuvant.