Epigenetic landscape of gastrointestinal stromal tumors: Mechanistic insights and therapeutic opportunities

doi:10.3748/wjg.v32.i17.118502

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 7, 2026; 32(17): 118502
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.118502

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Figure 1 Epigenetic mechanisms in gastrointestinal stromal tumors. DNA methylation and histone modifications disrupt tumor suppressor genes, developmental regulators, and stemness pathways, thereby promoting genomic instability, uncontrolled proliferation, and therapeutic resistance in gastrointestinal stromal tumors. GIST: Gastrointestinal stromal tumors; LINE-1: Long interspersed nuclear element-1; CD: Cluster of differentiation; PI3K: Phosphatidylinositol 3-kinase; AKT: Protein kinase B; mTOR: Mammalian target of rapamycin; DNMT: DNA methyltransferase; ICC: Interstitial cells of Cajal; m6A: N6-methyladenosine; ncRNA: Non-coding RNA; DMR: Differentially methylated region; miRNA: MicroRNA; MRP: Multidrug resistance protein 1; IFN: Interferon.

Citation: Papadakos SP, Mandrakis G, Siakavellas SI, Memos N, Gakiopoulou H, Schizas D, Theocharis S. Epigenetic landscape of gastrointestinal stromal tumors: Mechanistic insights and therapeutic opportunities. World J Gastroenterol 2026; 32(17): 118502
URL: https://www.wjgnet.com/1007-9327/full/v32/i17/118502.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i17.118502

Papadakos SP, Mandrakis G, Siakavellas SI, Memos N, Gakiopoulou H, Schizas D, Theocharis S. Epigenetic landscape of gastrointestinal stromal tumors: Mechanistic insights and therapeutic opportunities. World J Gastroenterol 2026; 32(17): 118502 [DOI: 10.3748/wjg.v32.i17.118502]

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