Clinical significance of autoantibody profiling and systemic inflammation in predicting outcomes of gastric cancer patients undergoing immunotherapy

doi:10.3748/wjg.v32.i17.117823

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 7, 2026; 32(17): 117823
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.117823

Table 3 The correlation between autoantibodies and tumor and inflammatory indicators

Characteristics	Negative (n = 67)	Positive (n = 163)	U value	P value
CEA (ng/mL), median (IQR)	37.46 (30.80, 41.74)	30.64 (24.16, 38.34)	3648	< 0.001
CA199 (U/mL), median (IQR)	45.32 (35.43, 58.40)	35.74 (27.80, 41.54)	2888	< 0.001
NLR, median (IQR)	8.15 (5.51, 9.46)	5.713 (4.93, 6.34)	2812	< 0.001
PLR, median (IQR)	222.4 (156.0, 363.9)	195.1 (106.5, 310.2)	4333	0.014
PIV, median (IQR)	1263 (1140, 1357)	1255 (957.0, 1408)	5458	0.996
SII, median (IQR)	1400 (917.4, 1844)	1377 (765.3, 2324)	5362	0.831

CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; PIV: Pan-immune-inflammation value; SII: Systemic immune-inflammation index.

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Citation: Zheng PM, Ouyang LB, Wang R, Jing KY, Gao HJ, Zhu CK. Clinical significance of autoantibody profiling and systemic inflammation in predicting outcomes of gastric cancer patients undergoing immunotherapy. World J Gastroenterol 2026; 32(17): 117823
URL: https://www.wjgnet.com/1007-9327/full/v32/i17/117823.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i17.117823

Zheng PM, Ouyang LB, Wang R, Jing KY, Gao HJ, Zhu CK. Clinical significance of autoantibody profiling and systemic inflammation in predicting outcomes of gastric cancer patients undergoing immunotherapy. World J Gastroenterol 2026; 32(17): 117823 [DOI: 10.3748/wjg.v32.i17.117823]

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