Clinical significance of autoantibody profiling and systemic inflammation in predicting outcomes of gastric cancer patients undergoing immunotherapy

doi:10.3748/wjg.v32.i17.117823

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 7, 2026; 32(17): 117823
Published online May 7, 2026. doi: 10.3748/wjg.v32.i17.117823

Table 1 Clinical and blood indicators characteristics of patients with gastric cancer undergoing immunotherapy, n (%)

Characteristics	Death (n = 157)	Survival (n = 73)	χ²/U value	P value
Age (years), median (IQR)	64 (57, 69)	63 (55, 70)	5561	0.718
Gender			2.465	0.120
Male	111 (70.7)	44 (60.3)
Female	46 (29.3)	29 (39.7)
TNM			16.04	< 0.001
I + II	7 (4.5)	15 (20.5)
III + IV	150 (95.5)	58 (79.5)
ANA			0.103	0.748
Negative	81 (51.6)	36 (49.3)
Positive	76 (48.4)	37 (50.7)
ENA			4.371	0.037
Negative	92 (58.6)	32 (43.8)
Positive	65 (41.4)	41 (56.2)
ANA + ENA			18.950	< 0.001
Negative	48 (30.6)	19 (26.0)
Positive	109 (69.4)	54 (74.0)

ANA: Antinuclear antibody; ENA: Extractable nuclear antigen; TNM: Tumor node metastasis; IQR: Interquartile range.

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Citation: Zheng PM, Ouyang LB, Wang R, Jing KY, Gao HJ, Zhu CK. Clinical significance of autoantibody profiling and systemic inflammation in predicting outcomes of gastric cancer patients undergoing immunotherapy. World J Gastroenterol 2026; 32(17): 117823
URL: https://www.wjgnet.com/1007-9327/full/v32/i17/117823.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i17.117823

Zheng PM, Ouyang LB, Wang R, Jing KY, Gao HJ, Zhu CK. Clinical significance of autoantibody profiling and systemic inflammation in predicting outcomes of gastric cancer patients undergoing immunotherapy. World J Gastroenterol 2026; 32(17): 117823 [DOI: 10.3748/wjg.v32.i17.117823]

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