Helicobacter pylori eradication and the prevention of peptic ulcer bleeding and cardiovascular disease progression in chronic aspirin users

Table 6 Prevalence of gastric lesions, cardiovascular disease status, and adverse events: Comparison among Helicobacter pylori eradicated, persistent (6-week and 6-month), and Helicobacter pylori-negative groups, n (%)

Category	Variable	H. pylori-positive group			H. pylori-negative group (n = 138)	P value (eradicated vs persistent 6-week post-treatment)	P value (persistent 6-month vs negative)
		Eradicated (n = 136)	Persistent 6-week post-treatment (n = 126)	Persistent 6-month follow-up (n = 126)
Gastric	PUB	5 (3.7)	26 (20.6)	15 (11.9)	0 (0.0)	< 0.001	< 0.001
Outcomes	Gastric erosions	8 (5.9)	26 (20.6)	12 (9.5)	0 (0.0)	< 0.001	< 0.001
	Gastric ulcer	6 (4.4)	22 (17.5)	10 (7.9)	0 (0.0)	< 0.001	< 0.001
	Antral erosion	2 (1.5)	6 (4.8)	2 (1.6)	0 (0.0)	0.02	0.06
	Duodenal ulcer	3 (2.2)	8 (6.3)	4 (3.2)	0 (0.0)	0.03	0.08
CV disease progression status1	CV disease progression	40 (29.4)	96 (76.2)	92 (73.0)	44 (32.0)	< 0.001	< 0.001
	PCI	10 (7.4)	11 (8.7)	10 (7.9)	15 (11.0)	0.05	0.06
	IHD-PCI	16 (11.8)	22 (17.5)	20 (15.9)	6 (4.3)	0.01	0.02
	CABG	12 (8.8)	30 (23.8)	28 (22.2)	17 (12.0)	0.002	0.005
	CSA	4 (2.9)	6 (4.8)	3 (2.4)	0 (0.0)	0.03	0.07
	Post CABG	5 (3.7)	12 (9.5)	10 (7.9)	4 (2.9)	0.07	0.08
	Post PCI	5 (3.7)	6 (4.8)	5 (4.0)	0 (0.0)	0.22	0.33
	Inferior MI	4 (2.9)	6 (4.8)	4 (3.2)	0 (0.0)	0.33	0.34
	Prosthetic MV	4 (2.9)	6 (4.8)	4 (3.2)	0 (0.0)	0.33	0.34
	Post PCS	4 (2.9)	6 (4.8)	4 (3.2)	0 (0.0)	0.22	0.33
Adverse events	Fatigue	4 (2.9)	14 (11.1)	10 (7.9)	8 (5.8)	0.01	0.02
	Dizziness	3 (2.2)	10 (7.9)	6 (4.8)	5 (3.6)	0.02	0.03
	Skin Rash	2 (1.5)	6 (4.8)	4 (3.2)	2 (1.4)	0.02	0.04

¹CV disease progression status at 6 months represent the presence of the condition (either pre-existing or newly progressed) at the 6-month follow-up assessment.

Comparisons between groups were performed using the χ² test. A P value < 0.05 was considered statistically significant. H. pylori: Helicobacter pylori; PUB: Peptic ulcer bleeding; IHD: Ischemic heart disease; PCI: Percutaneous coronary intervention; CABG: Coronary artery bypass graft; CSA: Chronic stable angina; MI: Myocardial infarction; MV: Mitral valve; PCS: Post-cardiac surgery; CV: Cardiovascular.