Niu Huang mitigates dextran sulfate sodium-induced colitis by modulating farnesoid X receptor activation and the complement 3/NLRP3 signaling pathway

Figure 7 Niu Huang attenuates ulcerative colitis by regulating the farnesoid X receptor activation. A and B: Protein expression level of farnesoid X receptor in colonic tissues (n = 4 in each group); C: Quantitative polymerase chain reaction analysis of the mRNA expression of Nr0b2 and Fgf15 (n = 5 in each group); D and E: Protein expression level of C3 in colonic tissues (n = 4 in each group); F and G: Pearson correlation analysis between C3 and farnesoid X receptor in the sigmoid colon and transverse colon. ^aP < 0.05 vs dextran sulfate sodium group, ^bP < 0.01 vs dextran sulfate sodium group. DSS: Dextran sulfate sodium; NHL: Low-dose Niu Huang group; NHH: High-dose Niu Huang group; Mes: Mesalamine group; GADPH: Glyceraldehyde 3-phosphate dehydrogenase; NR1H4: Nuclear receptor subfamily 1 group H member 4.