Niu Huang mitigates dextran sulfate sodium-induced colitis by modulating farnesoid X receptor activation and the complement 3/NLRP3 signaling pathway

Figure 2 Niu Huang alleviated the symptoms and colon injury in colitis mice. A: Body weight changes in mice of each group (n = 10 in each group); B: Disease active index; C: Representative images of the colon length; D: Colon length (n = 10 in each group); E: Representative hematoxylin and eosin staining images of colon tissues; F and G: Protein expression levels of occludin, claudin3, E-cadherin and leucine rich repeat containing G protein-coupled receptor 5 in colon tissues (n = 4 in each group). The original blots are presented in Supplementary Figures 2 and 3. ^aP < 0.05 vs dextran sulfate sodium group, ^bP < 0.01 vs dextran sulfate sodium group, ^cP < 0.001 vs dextran sulfate sodium group. DSS: Dextran sulfate sodium; Lgr5: Leucine rich repeat containing G protein-coupled receptor 5; NHL: Low-dose Niu Huang group; NHH: High-dose Niu Huang group; Mes: Mesalamine group; GADPH: Glyceraldehyde 3-phosphate dehydrogenase.