Qiweizhigan granule ameliorates metabolic dysfunction-associated steatohepatitis by modulating the galectin 3/tumor necrosis factor receptor-associated factor 6-mediated ferroptosis

Figure 4 Qiweizhigan granule modulates the expression of galectin 3. A and B: Protein expression and mRNA expression of galectin 3 (LGALS3) were verified among the normal, a choline-deficient, L-amino acid-defined high-fat diet, and Qiweizhigan granule groups; C: Distribution of LGALS3 protein across various cell types in liver tissue based on The Human Protein Atlas database was shown; D: Expression levels of LGALS3 mRNA in Kupffer cells, hepatocytes, and hepatic stellate cells from normal mouse liver were verified; E: Immunofluorescence results of LGALS3 among the normal, choline-deficient, L-amino acid-defined high-fat diet, and Qiweizhigan granule groups were performed. Data were presented as means ± SEM. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. CDAHFD: Choline-deficient, L-amino acid-defined high-fat diet; LGALS3: Galectin 3; QWZG: Qiweizhigan granule.