Research progress in the treatment of ulcerative colitis with natural products

Table 2 Summary of clinical trials of natural products for ulcerative colitis[134-142]

Natural product/active component	Trial design	Sample size	Ref.
Anthocyanin-rich extract	Multicenter, randomized, placebo-controlled, double-blind study	48	Biedermann et al[134]
Hudi enteric-coated capsule, modified Wumei pill, and Qingchang Wenzhong decoction	Multicenter, randomized, double-blind study	143	Li et al[135]
Zataria multiflora	Multicenter, randomized, placebo-controlled, triple-blind trial	92	Morvaridi et al[136]
Curcumin, resveratrol	Prospective multicenter three-arm RCT	48	Erol Doğan et al[137]
Zuoqing San	Single-center, double-blind study	126	Li et al[138]
1-kestose	Randomized, double-blind, placebo-controlled pilot trial	40	Ikegami et al[139]
Curcumin-QingDai	A retrospective multicenter adult cohort study	88	Yanai et al[140]
Icanbelimod	Single-center, double-blind study	28	Lickliter et al[141]
Pegmispotide	Double-blind study	29	Allegretti et al[142]

RCT: Randomized controlled trial.