Monomorphic epitheliotropic intestinal T-cell lymphoma: Clinical, endoscopic and pathological features

doi:10.3748/wjg.v32.i16.117259

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 28, 2026; 32(16): 117259
Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.117259

Table 1 Monomorphic epitheliotropic intestinal T-cell lymphoma clinical characteristics: Peking Union Medical College Hospital and literature cohort, %

Characteristic	PUMCH cohort (n = 26)	Literature cohort (n = 130)	P value
Clinical characteristics
Sex (male:female)	15:11	87:42	0.370
Median age, years (range)	61 (37-82)	61 (35-83)
Weight loss	73 (19/26)	46 (60/130)	0.012^a
Abdominal pain	65 (17/26)	59 (77/130)	0.558
Diarrhea	35 (9/26)	39 (51/130)	0.659
Fever	31 (8/26)	48 (21/44)	0.164
Intestinal obstruction	27 (7/26)	18 (23/130)	0.276
Intestinal perforation	31 (8/26)	35 (45/130)	0.705
Laboratory findings
Anemia	65 (13/20)	60 (31/52)	0.675
Hypoalbuminemia	83 (15/18)	92 (36/39)	0.368
Elevated CRP	90 (9/10)	86 (25/29)	1.000
Elevated LDH	0 (0/16)	31 (11/35)	0.011^a
Elevated β2-MG	100 (8/8)
Sites of involvement
Stomach	0	10 (13/126)	0.126
Small intestine	96 (25/26)	84 (106/126)	0.128
Colon and rectum	15 (4/26)	25 (32/126)	0.323
Imaging features
Bowel wall thickening	83 (15/18)	56 (54/96)	0.037^a
Bowel dilation	39 (7/18)	20 (19/96)	0.076
Lymph node enlargement	61 (11/18)	23 (22/96)	0.001^a
Endoscopic features
Diffuse involvement	60 (6/10)
Mucosal edema	100 (10/10)	27 (17/64)	< 0.001^a
Rough/granular surface	100 (10/10)	19 (12/64)	< 0.001^a
Villous blunting	90 (9/10)	23 (15/64)	< 0.001^a
Lymphangiectasia-like change	80 (8/10)
Mosaic pattern	40 (4/10)
Mucosal hyperemia	60 (6/10)	16 (10/64)	0.005^a
Nodular elevations	40 (4/10)	6 (4/64)	0.010^a
Erosion	20 (2/10)	17 (11/64)	1.000
Ulceration	30 (3/10)	66 (42/64)	0.042^a
Mass-like lesion	0	16 (10/64)	0.339

^aP < 0.05.

PUMCH: Peking Union Medical College Hospital; CRP: C-reactive protein; LDH: Lactate dehydrogenase; β2-MG: Β2-microglobulin.

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Citation: Jiang SJ, Ou CZ, Tang H, Li MH, Jia CW, Zhou WX, He ZYT, Li J, Zhang Y, Li JN. Monomorphic epitheliotropic intestinal T-cell lymphoma: Clinical, endoscopic and pathological features. World J Gastroenterol 2026; 32(16): 117259
URL: https://www.wjgnet.com/1007-9327/full/v32/i16/117259.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i16.117259

Jiang SJ, Ou CZ, Tang H, Li MH, Jia CW, Zhou WX, He ZYT, Li J, Zhang Y, Li JN. Monomorphic epitheliotropic intestinal T-cell lymphoma: Clinical, endoscopic and pathological features. World J Gastroenterol 2026; 32(16): 117259 [DOI: 10.3748/wjg.v32.i16.117259]

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