Longitudinal evolution of low anterior resection syndrome in ultra-low rectal cancer: A trend analysis of a propensity-matched cohort

doi:10.3748/wjg.v32.i16.116405

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 28, 2026; 32(16): 116405
Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.116405

Table 4 Multivariable logistic regression analysis of risk factors for low anterior resection syndrome at 1 month postoperatively

	β	SE	Wald χ²	df	P value	Exp(B)	95%CI for Exp(B)
	β	SE	Wald χ²	df	P value	Exp(B)	Lower	Upper
Tumor location (> 3 cm)	0.824	0.367	5.055	1	0.025	2.280	1.111	4.678
Gender (female)	0.210	0.321	0.425	1	0.514	1.233	0.657	2.315
Age (< 61.28 years)	-0.483	0.331	2.127	1	0.145	0.617	0.322	1.181
Blood type (A)			1.964	3	0.580
AB	-0.582	0.417	1.952	1	0.162	0.559	0.247	1.264
B	-0.237	0.639	0.137	1	0.711	0.789	0.225	2.762
O	-0.270	0.365	0.544	1	0.461	0.764	0.373	1.563
BMI (< 23.42 kg/m²)	0.330	0.315	1.092	1	0.296	1.390	0.749	2.579
Diabetes (no)	0.232	0.401	0.334	1	0.563	1.261	0.575	2.765
Hypertension (no)	-0.224	0.339	0.436	1	0.509	0.799	0.411	1.553
Tumor pathology (adenocarcinoma)			1.270	3	0.736
Neuroendocrine carcinoma	19.502	40192.969	0.000	1	1.000	294868049.288	0.000
Signet ring cell carcinoma	19.821	28180.122	0.000	1	0.999	405570330.801	0.000
Mucinous adenocarcinoma	-0.820	0.728	1.270	1	0.260	0.440	0.106	1.834
TNM (0)			1.333	4	0.856
I	-0.127	0.522	0.059	1	0.808	0.881	0.317	2.449
II	-0.150	0.548	0.075	1	0.785	0.861	0.294	2.521
III	-0.356	0.633	0.315	1	0.574	0.701	0.203	2.424
IV	0.442	0.761	0.337	1	0.562	1.555	0.350	6.912
Postoperative complications (no)	-0.574	0.699	0.674	1	0.412	0.563	0.143	2.216
Neoadjuvant chemotherapy (no)	0.197	0.442	0.199	1	0.656	1.217	0.512	2.893
Neoadjuvant radiotherapy (no)	-0.177	0.460	0.149	1	0.700	0.838	0.340	2.062
Constant	1.273	0.928	1.883	1	0.170	3.572

Age and body mass index were converted into binary variables using the mean as the cutoff. Reference categories are shown in parentheses. BMI: Body mass index.

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Citation: Wang HS, Lin YX, Xu SR, Wang LY, Wang XD, Huang MJ. Longitudinal evolution of low anterior resection syndrome in ultra-low rectal cancer: A trend analysis of a propensity-matched cohort. World J Gastroenterol 2026; 32(16): 116405
URL: https://www.wjgnet.com/1007-9327/full/v32/i16/116405.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i16.116405

Wang HS, Lin YX, Xu SR, Wang LY, Wang XD, Huang MJ. Longitudinal evolution of low anterior resection syndrome in ultra-low rectal cancer: A trend analysis of a propensity-matched cohort. World J Gastroenterol 2026; 32(16): 116405 [DOI: 10.3748/wjg.v32.i16.116405]

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