Age-related gut microbiome profile and reversal of microbial imbalance by trimetazidine intervention

doi:10.3748/wjg.v32.i16.115969

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 28, 2026; 32(16): 115969
Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.115969

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Figure 7 Phenotypic studies of trimetazidine regulation of fatty acid oxidation and aging. A: Immunohistochemical staining of P21 and HADHB in liver tissues; B: Statistical analysis; C-F: The protein and messenger RNA levels of P21 and HADHB in liver tissues (n = 3 biological replicates) and statistical analysis (mean ± SEM, n = 3). ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. T48W: Trimetazidine intervention group collected at 48 weeks; H48W: Healthy control group collected at 48 weeks; AOD: Average optical density; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; mRNA: Messenger RNA.

Citation: Wang XM, Rao BC, Su GY, Wang HY, Zhang GZ, Ge FL, Yu ZJ, Ren ZG, Liang HX. Age-related gut microbiome profile and reversal of microbial imbalance by trimetazidine intervention. World J Gastroenterol 2026; 32(16): 115969
URL: https://www.wjgnet.com/1007-9327/full/v32/i16/115969.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i16.115969

Wang XM, Rao BC, Su GY, Wang HY, Zhang GZ, Ge FL, Yu ZJ, Ren ZG, Liang HX. Age-related gut microbiome profile and reversal of microbial imbalance by trimetazidine intervention. World J Gastroenterol 2026; 32(16): 115969 [DOI: 10.3748/wjg.v32.i16.115969]

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