Age-related gut microbiome profile and reversal of microbial imbalance by trimetazidine intervention

Figure 6 Trimetazidine intervention modulates gut microbiota composition and lipid metabolism of healthy aging rats. A and B: At the genus level, average relative abundance analysis of differential microbiota after treatment with trimetazidine for 10 weeks (A) and 48 weeks (B); C: At the genus level, correlation analysis between microbial abundance and age; D and E: Kyoto Encyclopedia of Genes and Genomes (KEGG) module analysis in the trimetazidine intervention group collected at 10 weeks and healthy control group collected at 10 weeks (P < 0.05, linear discriminant analysis > 3.0); F: Gut microbe functional potential in the trimetazidine intervention group collected at 48 weeks and healthy control group collected at 48 weeks determined by KEGG analysis. T10W: Trimetazidine intervention group collected at 10 weeks; T48W: Trimetazidine intervention group collected at 48 weeks; H10W: Healthy control group collected at 10 weeks; H48W: Healthy control group collected at 48 weeks; HR: Healthy rat cohort; HR2: Aged 2 weeks; HR10: Aged 10 weeks; HR20: Aged 20 weeks; HR48: Aged 48 weeks; LDA: Linear discriminant analysis.