Age-related gut microbiome profile and reversal of microbial imbalance by trimetazidine intervention

Figure 4 Lipid metabolism associated gut microbiota is significantly enriched in both healthy natural aging population and healthy rat cohorts. A: Functional prediction of the gut microbiota based on Kyoto Encyclopedia of Genes and Genomes pathways in the healthy natural aging population (HP) group, highlighting key metabolic modules; B: The bar plot of microbial abundance shows a progressive enrichment of lipid metabolism-associated microbiota; C: Gut microbiota lipid metabolism pathway analysis of the HP group; D: The abundance of lipid metabolism-associated microbes in the HP group; E-G: Bar chart showing the abundance of microbes enriched in lipid metabolism, fatty acid biosynthesis and degradation metabolic pathways; H and I: Correlation analysis between the gut microbiota and lipid metabolism-associated pathways of the HP group (H) and the healthy rat cohort (P < 0.05, false discovery rate corrected) (I). ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. S0-S9 indicate the healthy natural aging population group was categorized into ten subgroups based on age (n = 30 for each group). HR: Healthy rat cohort; HR2: Aged 2 weeks; HR10: Aged 10 weeks; HR20: Aged 20 weeks; HR48: Aged 48 weeks; LDA: Linear discriminant analysis; KEGG: Kyoto Encyclopedia of Genes and Genomes.