Deep learning-based multimodal model for predicting on-treatment histological outcomes in chronic hepatitis B-associated advanced liver fibrosis

Table 2 Univariate and multivariate analysis of the clinical variables associated with fibrosis reversal

Characteristics	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
PT (seconds)	1.333 (1.005-1.766)	0.046	1.200 (0.896-1.609)	0.222
ALP (U/L)	1.016 (1.000-1.031)	0.044	1.006 (0.990-1.023)	0.462
LSM (kPa)	1.092 (1.025-1.163)	0.007	1.073 (1.003-1.149)	0.041
Age (years)	1.111 (0.500-2.470)	0.796
Sex	1.008 (0.464-2.190)	0.983
Drinking	0.975 (0.371-2.562)	0.959
Smoking	0.700 (0.262-1.872)	0.477
BMI (kg/m2)	1.027 (0.931-1.133)	0.591
PLT (109/L)	0.996 (0.989-1.002)	0.169
ALB (g/L)	1.011 (0.924-1.106)	0.809
ALT (IU/L)	1.000 (0.996-1.005)	0.931
AST (IU/L)	0.999 (0.992-1.006)	0.793
GGT (U/L)	0.999 (0.997-1.001)	0.432
TBil (μmol/L)	1.053 (0.983-1.129)	0.142
AFP (ng/mL)	1.006 (0.993-1.018)	0.376
APRI	1.001 (0.716-1.397)	0.997
FIB4	1.058 (0.830-1.350)	0.648
HBsAg1	0.783 (0.449-1.366)	0.389
HBV DNA1	0.833 (0.651-1.066)	0.146

¹Represents log10 IU/mL.

OR: Odds ratio; CI: Confidence interval; PT: Prothrombin time; ALP: Alkaline phosphatase; LSM: Liver stiffness measurement; BMI: Body mass index; PLT: Platelet count; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyltransferase; TBiL: Total bilirubin; AFP: Alpha-fetoprotein; APRI: Aspartate aminotransferase to platelet index; FIB4: Fibrosis index based on 4 factors; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus.