Lymph node regression grade as a prognostic marker in rectal cancer after neoadjuvant therapy and radical resection

doi:10.3748/wjg.v32.i15.116026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 21, 2026; 32(15): 116026
Published online Apr 21, 2026. doi: 10.3748/wjg.v32.i15.116026

Table 6 Association of lymph node regression grade with the factors relating to survival in subgroup, n = 63

Patients characteristics	LRG	2	3	4	5	Value	P value
Gender						χ²_cmh = 3.61	0.06
Male	45	4 (8.89)	10 (22.22)	9 (20.00)	22 (48.89)
Female	18	5 (27.78)	4 (22.22)	4 (22.22)	5 (27.78)
Age (years)						χ²_cmh = 1.74	0.19
< 50	28	5 (17.86)	7 (25.00)	7 (25.00)	9 (32.14)
≥ 50	35	4 (11.43)	7 (20.00)	6 (17.14)	18 (51.43)
Post-CRT CEA (ng/mL)						χ²_cmh = 0.79	0.37
< 5	41	7 (17.07)	11 (26.83)	5 (12.20)	18 (43.90)
≥ 5	22	2 (9.09)	3 (13.64)	8 (36.36)	9 (40.91)
Post-CRT CA19-9 (U/mL)						χ²_cmh = 4.47	0.03
< 37	57	9 (15.79)	14 (24.56)	12 (21.05)	22 (38.60)
≥ 37	6	0 (0)	0 (0)	1 (16.67)	5 (83.33)
Distance from anal verge (cm)						χ²_cmh = 0.11	0.74
< 5	31	4 (12.90)	7 (22.58)	6 (19.35)	14 (45.16)
≥ 5	32	5 (15.63)	7 (21.88)	7 (21.88)	13 (40.63)
Operation						χ²_cmh = 0.02	0.90
LAR	44	6 (13.64)	11 (25.00)	8 (18.18)	19 (43.18)
APR	19	3 (15.79)	3 (15.79)	5 (26.32)	8 (42.11)
cTNM						χ²_cmh = 2.13	0.35
I	2	0 (0)	0 (0)	1 (50.00)	1 (50.00)
II	14	0 (0)	4 (28.57)	4 (28.57)	6 (42.86)
III	30	7 (23.33)	7 (23.33)	4 (13.33)	12 (40.00)
ypT						χ²_cmh = 3.65	0.06
ypT0	3	1 (33.33)	1 (33.33)	1 (33.33)	0 (0)
ypT1	1	0 (0)	1 (100.00)	0 (0)	0 (0)
ypT2	7	1 (14.29)	1 (14.29)	3 (42.86)	2 (28.57)
ypT3	50	7 (14.00)	11 (22.00)	9 (18.00)	23 (46.00)
ypT4	2	0 (0)	0 (0)	0 (0)	2 (100.00)
ypN						χ²_cmh = 3.52	0.06
ypN1	35	6 (17.14)	9 (25.71)	10 (28.57)	10 (28.57)
ypN2	28	3 (10.71)	5 (17.86)	3 (10.71)	17 (60.71)
Tumor differentiation degree						χ²_cmh = 0.72	0.40
Well/moderate	48	7 (14.58)	11 (22.92)	12 (25.00)	18 (37.50)
Poor	15	2 (13.33)	3 (20.00)	1 (6.67)	9 (60.00)
TRG						χ²_cmh = 9.32	0.002
TRG1	3	1 (33.33)	1 (33.33)	1 (33.33)	0 (0)
TRG2	9	4 (44.44)	3 (33.33)	0 (0)	2 (22.22)
TRG3	26	3 (11.54)	6 (23.08)	4 (15.38)	13 (50.00)
TRG4	19	1 (5.26)	4 (21.05)	6 (31.58)	8 (42.11)
TRG5	6	0 (0)	0 (0)	2 (33.33)	4 (66.67)

LRG: Lymph node regression grade; CRT: Chemoradiotherapy; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; LAR: Low anterior resection; APR: Abdominoperineal resection; cTNM: Clinical tumor-node-metastasis; TRG: Tumor regression grade; cmh: Cochran-Mantel-Haenszel.

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Citation: Shi YJ, Duan PP, Liu QQ, Ru HY, Huang YJ, Xia W, Chen L, Li X. Lymph node regression grade as a prognostic marker in rectal cancer after neoadjuvant therapy and radical resection. World J Gastroenterol 2026; 32(15): 116026
URL: https://www.wjgnet.com/1007-9327/full/v32/i15/116026.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i15.116026

Shi YJ, Duan PP, Liu QQ, Ru HY, Huang YJ, Xia W, Chen L, Li X. Lymph node regression grade as a prognostic marker in rectal cancer after neoadjuvant therapy and radical resection. World J Gastroenterol 2026; 32(15): 116026 [DOI: 10.3748/wjg.v32.i15.116026]

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