Wuda granules target estrogen receptors and modulate gut microbiota to alleviate postoperative ileus: A multi-omics perspective

Figure 6 Molecular docking of representative chemical constituents from Wuda granules with estrogen receptors. A: Binding modes of linderane, quercetin, and quercitrin with estrogen receptor α (PDB ID: 1a52); B: Binding modes of linderane and quercetin with estrogen receptor β (PDB ID: 5toa). Electrostatic surface representations (left), binding pocket interactions (middle), and two-dimensional interaction diagrams (right) are shown. The interaction types are indicated by different colors: Hydrogen bonds, yellow; hydrophobic interactions, blue; and salt bridges, orange. ER: Estrogen receptor.