Development and validation of a deep-learning-based diagnostic model for drug-induced liver injury using computed tomography images

doi:10.3748/wjg.v32.i15.114778

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 21, 2026; 32(15): 114778
Published online Apr 21, 2026. doi: 10.3748/wjg.v32.i15.114778

Table 4 Patient-level performance of doctors and model 96 in the internal test cohort (n = 37)

Item	Accuracy (95%CI)	P value¹	Sensitivity (95%CI)	P value	Specificity (95%CI)	P value	Youden index	Kappa value
Residents of internal medicine	0.541 (0.369-0.705)	0.002^b	0.750 (0.349-0.968)	1.000	0.483 (0.294-0.675)	0.003^b	0.233	0.147
Attending physicians	0.730 (0.559-0.862)	0.227	0.750 (0.349-0.968)	1.000	0.724 (0.528-0.873)	0.289	0.474	0.373
Residents of radiology	0.676 (0.502-0.820)	0.039^a	0.875 (0.473-0.997)	1.000	0.621 (0.423-0.793)	0.039^a	0.496	0.341
Attending radiologists	0.865 (0.712-0.955)	1.000	0.625 (0.245-0.915)	0.500	0.931 (0.772-0.992)	0.687	0.556	0.582
Model 96	0.865 (0.712-0.955)		0.875 (0.473-0.997)		0.862 (0.683-0.961)		0.737	0.649

¹The P values were compared with model 96 and presented without adjustment for multiple comparisons.

^aP < 0.05.

^bP < 0.01.

CI: Confidence interval.

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Citation: Wang SY, Yin SQ, Yang JY, Ji MY, Zeng XQ, Rao SX, Lv MZ, Bao J, Wang MN, Gao H. Development and validation of a deep-learning-based diagnostic model for drug-induced liver injury using computed tomography images. World J Gastroenterol 2026; 32(15): 114778
URL: https://www.wjgnet.com/1007-9327/full/v32/i15/114778.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i15.114778

Wang SY, Yin SQ, Yang JY, Ji MY, Zeng XQ, Rao SX, Lv MZ, Bao J, Wang MN, Gao H. Development and validation of a deep-learning-based diagnostic model for drug-induced liver injury using computed tomography images. World J Gastroenterol 2026; 32(15): 114778 [DOI: 10.3748/wjg.v32.i15.114778]

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