Roles of hepatic immunity in metabolic dysfunction-associated steatotic liver disease: Cellular and molecular mechanisms and clinical trials

Figure 2 Molecular signaling pathways involved in macrophage function in metabolic dysfunction-associated steatotic liver disease. AMPKα: Adenosine monophosphate-activated protein kinase α; PTPRO: Protein tyrosine phosphatase receptor type O; ROS: Reactive oxygen species; NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells; IL: Interleukin; TNF: Tumor necrosis factor; NLRP3: NOD-like receptor family pyrin domain containing 3; Tim-4: T-cell membrane protein 4; LKB1: Liver kinase B1; Trem2: Triggering receptor expressed on myeloid cells 2; ER: Endoplasmic reticulum.