Thalidomide for refractory hemorrhagic chronic radiation proctitis secondary to pelvic malignancy radiotherapy: A phase II clinical trial

doi:10.3748/wjg.v32.i14.116529

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Apr 14, 2026; 32(14): 116529
Published online Apr 14, 2026. doi: 10.3748/wjg.v32.i14.116529

Table 3 Before and after thalidomide treatment effects on hemorrhagic chronic radiation proctitis, median (interquartile range)

	Pre-treatment	Post-treatment	P value
SOMA (n = 62)	3 (3, 4)	1 (1, 2)	< 0.001
VRS (n = 35)	3 (3, 3)	3 (2, 3)	0.132
Mucosal congestion	2 (2, 2)	2 (1, 2)	0.007
Telangiectasia	3 (3, 3)	3 (2, 3)	0.257
Ulceration	0 (0, 3)	0 (0, 0)	0.177
Stenosis	0 (0, 0)	0 (0, 0)	0.317
Necrosis	0 (0, 0)	0 (0, 0)	1.000
Hemoglobin, g/L (n = 32)	117.5 (103, 125.5)	108.5 (103, 125.25)	0.199

SOMA: Subjective Objective Management Analysis system; VRS: Vienna Rectoscopy Score.

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Citation: Huang XY, Zhong QH, Kuang YY, Li ZJ, Huang BJ, He YJ, Zhu MM, Guan Q, Li XY, Qin QY, Ma TH. Thalidomide for refractory hemorrhagic chronic radiation proctitis secondary to pelvic malignancy radiotherapy: A phase II clinical trial. World J Gastroenterol 2026; 32(14): 116529
URL: https://www.wjgnet.com/1007-9327/full/v32/i14/116529.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i14.116529

Huang XY, Zhong QH, Kuang YY, Li ZJ, Huang BJ, He YJ, Zhu MM, Guan Q, Li XY, Qin QY, Ma TH. Thalidomide for refractory hemorrhagic chronic radiation proctitis secondary to pelvic malignancy radiotherapy: A phase II clinical trial. World J Gastroenterol 2026; 32(14): 116529 [DOI: 10.3748/wjg.v32.i14.116529]

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