Xpert Ultra and TrueNat MTB plus assays for the diagnosis of gastrointestinal tuberculosis: A diagnostic accuracy study

doi:10.3748/wjg.v32.i14.116088

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 14, 2026; 32(14): 116088
Published online Apr 14, 2026. doi: 10.3748/wjg.v32.i14.116088

Table 3 Diagnostic accuracy of Xpert Ultra and TrueNat MTB Plus, % (95% confidence interval)

		Sensitivity	Specificity	PPV	NPV	Accuracy
Xpert Ultra	Definite GITB	66.67 (9.4-99.2)	83.33 (51.6-97.9)	50 (18.3-81.7)	90.91 (66.4-98)	80 (51.9-95.7)
	Probable GITB	65.22 (42.7-83.6)		88.24 (67.2-96.5)	55.56 (40.4-69.8)	71.43 (53.7-85.4)
	Overall	65.38 (44.3-82.8)		89.47 (69.9-96.9)	52.63 (38.2-66.6)	71.05 (54.1-84.6)
TrueNat MTB Plus	Definite GITB	66.67 (9.4-99.2)	50 (21.1-78.9)	25 (11.1-47)	85.71 (52.4-97)	53.33 (26.6-78.7)
	Probable GITB	56.52 (34.5-76.8)		68.42 (52.6-80.9)	37.5 (22.4-55.5)	54.29 (36.7-71.2)
	Overall	57.69 (36.9-76.7)		71.43 (56.5-82.8)	35.29 (20.9-52.9)	55.26 (38.3-71.4)

GITB: Gastrointestinal tuberculosis; PPV: Positive predictive value; NPV: Negative predictive value.

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Citation: Sharma K, Jindal N, Sharma M, Mandavdhare HS, Gupta P, Sekar A, Dutta U, Sharma V. Xpert Ultra and TrueNat MTB plus assays for the diagnosis of gastrointestinal tuberculosis: A diagnostic accuracy study. World J Gastroenterol 2026; 32(14): 116088
URL: https://www.wjgnet.com/1007-9327/full/v32/i14/116088.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i14.116088

Sharma K, Jindal N, Sharma M, Mandavdhare HS, Gupta P, Sekar A, Dutta U, Sharma V. Xpert Ultra and TrueNat MTB plus assays for the diagnosis of gastrointestinal tuberculosis: A diagnostic accuracy study. World J Gastroenterol 2026; 32(14): 116088 [DOI: 10.3748/wjg.v32.i14.116088]

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