Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study

doi:10.3748/wjg.v32.i14.115790

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 14, 2026; 32(14): 115790
Published online Apr 14, 2026. doi: 10.3748/wjg.v32.i14.115790

Table 2 Baseline characteristics for aspirin or clopidogrel alone users, n (%)

Variables	Aspirin-alone users (n = 55295)	Clopidogrel-alone users (n = 6882)	Concurrent users of aspirin & clopidogrel (n = 7080)	Concomitant users of aspirin & clopidogrel (n = 22452)
Age, median (IQR)	61 (52-69)	65 (56-73)	65 (57-73)	63 (54-70)
Sex
Male	28344 (51.3)	3465 (50.3)	5081 (71.8)	15176 (67.6)
Female	26951 (48.7)	3417 (49.7)	1999 (28.2)	7276 (32.4)
Mucosal DAs
Aspirin	55295 (100)	0 (0)	7080 (100)	22452 (100)
Clopidogrel	0 (0)	6882 (100)	7080 (100)	22452 (100)
PAs co-administered with DAs
PPI	5737 (31.8)	715 (31.9)	742 (23.1)	3745 (30.3)
Rebamipide	2143 (11.9)	450 (20.1)	224 (7.0)	1484 (12.0)
H2RA	8065 (44.7)	927 (41.4)	2187 (68.0)	6503 (52.5)
Others	2085 (11.6)	147 (6.6)	63 (1.9)	643 (5.2)

IQR: Interquartile range; DA: Damaging agent; PA: Protective agent; H2RA: H2-receptor antagonist; PPI: Proton pump inhibitor; Others: Agents such as sodium alginate, ecabet sodium hydrate, polaprezinc, and stillen (an ethanol extract of Artemisiae Argyi herba).

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Citation: Kim M, Chi SA, Kim JE, Kim ER, Hong SN, Kim YH, Kim K, Chang DK. Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study. World J Gastroenterol 2026; 32(14): 115790
URL: https://www.wjgnet.com/1007-9327/full/v32/i14/115790.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i14.115790

Kim M, Chi SA, Kim JE, Kim ER, Hong SN, Kim YH, Kim K, Chang DK. Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study. World J Gastroenterol 2026; 32(14): 115790 [DOI: 10.3748/wjg.v32.i14.115790]

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