MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer

Figure 4 Interferon-γ, tumor necrosis factor-α, interleukin-1β, and interleukin-18 secreted were increased in correlation with the concentration of Xiangshaliujunzi decoction in BGC-823/5-fluorouracil cells treated with Xiangshaliujunzi decoction. A: Interferon-γ; B: Tumor necrosis factor-α; C: Interleukin (IL)-1β; D: IL-18. L-Xiangshaliujunzi decoction (XSLJZD): 1.55 g/(kg·day); M-XSLJZD: 3.1 g/(kg·day); H- XSLJZD: 6.2 g/(kg·day). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs control. XSLJZD: Xiangshaliujunzi decoction; IFN: Interferon; TNF: Tumor necrosis factor; IL: Interleukin.