Optimal cannabinoid-terpene combination ratios suppress mutagenicity of gastric reflux in normal and metaplastic esophageal cells

Figure 6 Dysregulation of G-protein coupled receptor gene expression in clinical Barrett’s esophagus and Barrett’s esophagus-associated esophageal adenocarcinoma. A: The volcano represents differentially expressed genes in clinical Barrett’s esophagus (BE) (n = 8) compared to the normal esophageal epithelium (n = 8). The data were obtained from the GSE database (GSE1420). BE upregulated (blue) and downregulated (red) genes were identified using the GEO2R tool, based on log₂ fold change > 0.9 and adjusted P values of < 0.05; B: The volcano represents differentially expressed genes in clinical BE-associated esophageal adenocarcinoma (EAC) (n = 8) compared to the normal esophageal epithelium (n = 8). The data were obtained from the GSE database (GSE1420). EAC upregulated (blue) and downregulated (red) genes were identified using the GEO2R tool, based on log₂ fold change > 0.9 and adjusted P values of < 0.05.