Optimal cannabinoid-terpene combination ratios suppress mutagenicity of gastric reflux in normal and metaplastic esophageal cells

Figure 2 The effect of cannabigerol and phytol on the proliferation and apoptosis of deoxycholic acid-damaged esophageal cells. A: XTT cell viability assay of HET1A cells subjected to 100 μmol/L deoxycholic acid (DCA) or vehicle control treatment for 24 hours in the presence or absence of cannabigerol (CBG) and phytol (Phy); B: The plot represents a non-linear regression analysis of the percentage of apoptotic cells in the HET1A cell line cultured with or without CBG/Phy pretreatment and exposed to DCA at concentrations ranging from 0 μmol/L to 500 μmol/L. DCA: Deoxycholic acid; EC50: Lethal dose 50%; CBG: Cannabigerol; Phy: Phytol.