Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial

doi:10.3748/wjg.v32.i13.117115

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 7, 2026; 32(13): 117115
Published online Apr 7, 2026. doi: 10.3748/wjg.v32.i13.117115

Table 3 Summary of treatment-emergent adverse events, n (%)

TEAEs¹	LPZ + FM (n = 92)	LPZ + placebo (n = 91)
Patients with any TEAEs	30 (32.6)	21 (23.1)
Drowsiness	11 (12.0)	4 (4.4)
Dry mouth	7 (7.6)	5 (5.5)
Diarrheal	6 (6.5)	7 (7.7)
Insomnia	4 (4.3)	2 (2.2)
Nausea	4 (4.3)	3 (3.3)
Constipation	1 (1.1)	3 (3.3)

¹A patient was counted only once, even if the same event was reported multiple times by the patient.

LPZ: Lansoprazole; FM: Flupentixol-melitracen; TEAEs: Treatment-emergent adverse events.

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Citation: Wang XY, Yin KH, Cheng L, Wang XY, Qiao Y, Tang XR, Wang B, Yan XJ, Chen SL. Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial. World J Gastroenterol 2026; 32(13): 117115
URL: https://www.wjgnet.com/1007-9327/full/v32/i13/117115.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i13.117115

Wang XY, Yin KH, Cheng L, Wang XY, Qiao Y, Tang XR, Wang B, Yan XJ, Chen SL. Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial. World J Gastroenterol 2026; 32(13): 117115 [DOI: 10.3748/wjg.v32.i13.117115]

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