MassARRAY-based KRAS and GNAS hotspot mutation analysis of cystic fluid enables accurate classification of pancreatic cystic lesions

doi:10.3748/wjg.v32.i13.115710

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 7, 2026; 32(13): 115710
Published online Apr 7, 2026. doi: 10.3748/wjg.v32.i13.115710

Table 2 Summary of hotspot mutation analysis, n (%)

Hotspot mutation		IPMNs (n = 23)	MCNs (n = 36)	SCAs (n = 32)	Non-neoplastic cysts (n = 10)
KRAS	Wild type	14 (60.9)	25 (69.4)	32 (100)	10 (100)
	Hotspot mutation	9 (39.1)	11 (30.6)	0 (0)	0 (0)
	G12D	3 (13)	3 (8.3)	0 (0)	0 (0)
	G12V	4 (17.4)	4 (11.1)	0 (0)	0 (0)
	G12R	0 (0)	1 (2.8)	0 (0)	0 (0)
	Q61H¹	1 (4.3)	2 (5.6)	0 (0)	0 (0)
	A146V²	4 (17.4)	3 (8.3)	0 (0)	0 (0)
GNAS	Wild type	11 (47.8)	36 (100)	32 (100)	10 (100)
	Hotspot mutation	12 (52.2)	0 (0)	0 (0)	0 (0)
	R201C	4 (17.4)	0 (0)	0 (0)	0 (0)
	R201H	8 (34.8)	0 (0)	0 (0)	0 (0)

¹One mucinous cystic neoplasm cystic fluid sample did not call any results at KRAS codon 61.

²Two serous cystadenomas cystic fluid samples did not call any results at KRAS codon 146.

IPMNs: Intraductal papillary mucinous neoplasms; MCNs: Mucinous cystic neoplasms; SCAs: Serous cystadenomas.

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Citation: Diao WF, Cui M, Chen TQ, Xiao JH, Yang S, Zheng QY, Xu RY, Han XL, Hu Y. MassARRAY-based KRAS and GNAS hotspot mutation analysis of cystic fluid enables accurate classification of pancreatic cystic lesions. World J Gastroenterol 2026; 32(13): 115710
URL: https://www.wjgnet.com/1007-9327/full/v32/i13/115710.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i13.115710

Diao WF, Cui M, Chen TQ, Xiao JH, Yang S, Zheng QY, Xu RY, Han XL, Hu Y. MassARRAY-based KRAS and GNAS hotspot mutation analysis of cystic fluid enables accurate classification of pancreatic cystic lesions. World J Gastroenterol 2026; 32(13): 115710 [DOI: 10.3748/wjg.v32.i13.115710]

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