Reprogramming of amino acid metabolism in cholangiocarcinoma: A potential target for metabolic-targeted therapy

doi:10.3748/wjg.v32.i13.115536

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Apr 7, 2026; 32(13): 115536
Published online Apr 7, 2026. doi: 10.3748/wjg.v32.i13.115536

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Figure 6 The alteration of the urea cycle’s enzymes in cholangiocarcinoma progression. Alteration of enzymes in the urea cycle is associated with aggressive phenotypes of cholangiocarcinoma (CCA) cells and poor clinicopathological characteristics of patients. The up or down direction of the arrows indicates increased or decreased levels in CCA cells. CPS1: Carbamoyl phosphate synthetase 1; OTC: Ornithine transcarbamylase; ASS: Argininosuccinate synthetase; ASL: Argininosuccinate lyase; ARG: Arginase.

Citation: Khawkhiaw K, Lert-Itthiporn W, Seyedasli N, Chiu CF, Saengboonmee C. Reprogramming of amino acid metabolism in cholangiocarcinoma: A potential target for metabolic-targeted therapy. World J Gastroenterol 2026; 32(13): 115536
URL: https://www.wjgnet.com/1007-9327/full/v32/i13/115536.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i13.115536

Khawkhiaw K, Lert-Itthiporn W, Seyedasli N, Chiu CF, Saengboonmee C. Reprogramming of amino acid metabolism in cholangiocarcinoma: A potential target for metabolic-targeted therapy. World J Gastroenterol 2026; 32(13): 115536 [DOI: 10.3748/wjg.v32.i13.115536]

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