Berberine alleviates experimental colitis by enhancing gut-microbiota-dependent intestinal barrier function and suppressing gasdermin D activation

Figure 8 An inhibitory drug targeting gasdermin D attenuates the symptoms of dextran sulfate sodium-induced colitis. A: Schematic representation of the experiments; B: Percentage change in body weight; C: Disease activity index score; D: Changes in colon length; E: Micrographs of hematoxylin and eosin staining; F: Histopathological scoring of colon tissue. The data shown are the mean ± SEM (n = 8). ^aP < 0.05, ^cP < 0.001. PBS: Phosphate-buffered saline; Berb-H: Berberine high-dose group; DSS: Dextran sulfate sodium; DAI: Disease activity index.